Abrogation of Complex Glycosylation by Swainsonine Results in Strain- and Cell-specific Inhibition of Prion Replication

Neuroblastoma-derived N2a-PK1 cells, fibroblastic LD9 cells, and CNS-derived CAD5 cells can be infected efficiently and persistently by various prion strains, as measured by the standard scrapie cell assay. Swainsonine, an inhibitor of Golgi α-mannosidase II that causes abnormal N-glycosylation, str...

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Hlavní autoři: Browning, Shawn, Baker, Christopher A., Smith, Emery, Mahal, Sukhvir P., Herva, Maria E., Demczyk, Cheryl A., Li, Jiali, Weissmann, Charles
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2011
Témata:
Molecular Bases of Disease
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3220511/
https://ncbi.nlm.nih.gov/pubmed/21930694
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.283978
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