Mechanistic Studies of Substrate-assisted Inhibition of Ubiquitin-activating Enzyme by Adenosine Sulfamate Analogues

Ubiquitin-activating enzyme (UAE or E1) activates ubiquitin via an adenylate intermediate and catalyzes its transfer to a ubiquitin-conjugating enzyme (E2). MLN4924 is an adenosine sulfamate analogue that was identified as a selective, mechanism-based inhibitor of NEDD8-activating enzyme (NAE), anot...

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Autori principali: Chen, Jesse J., Tsu, Christopher A., Gavin, James M., Milhollen, Michael A., Bruzzese, Frank J., Mallender, William D., Sintchak, Michael D., Bump, Nancy J., Yang, Xiaofeng, Ma, Jingya, Loke, Huay-Keng, Xu, Qing, Li, Ping, Bence, Neil F., Brownell, James E., Dick, Lawrence R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2011
Soggetti:
Enzymology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3220466/
https://ncbi.nlm.nih.gov/pubmed/21969368
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.279984
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