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Inhibition of HeLa cell DNA topoisomerase I by ATP and phosphate.

The relaxation activity of DNA topoisomerase I from HeLa cell nuclei is strongly inhibited by a variety of purine nucleotides in the presence but not absence of 1 mM potassium phosphate. For ATP, 3-4 mM causes nearly complete inhibition. The 2'-and 3'-AMP isomer are active as well in the p...

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Autori principali: Low, R L, Holden, J A
Natura: Artigo
Lingua:Inglês
Pubblicazione: 1985
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC322018/
https://ncbi.nlm.nih.gov/pubmed/2997732
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