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Inhibition of HeLa cell DNA topoisomerase I by ATP and phosphate.
The relaxation activity of DNA topoisomerase I from HeLa cell nuclei is strongly inhibited by a variety of purine nucleotides in the presence but not absence of 1 mM potassium phosphate. For ATP, 3-4 mM causes nearly complete inhibition. The 2'-and 3'-AMP isomer are active as well in the p...
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| Главные авторы: | , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
1985
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| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC322018/ https://ncbi.nlm.nih.gov/pubmed/2997732 |
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