Elevated Glucose Represses Liver Glucokinase and Induces Its Regulatory Protein to Safeguard Hepatic Phosphate Homeostasis

OBJECTIVE: The induction of hepatic glucose 6-phosphatase (G6pc) by glucose presents a paradox of glucose-induced glucose intolerance. We tested whether glucose regulation of liver gene expression is geared toward intracellular homeostasis. RESEARCH DESIGN AND METHODS: The effect of glucose-induced...

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Main Authors: Arden, Catherine, Petrie, John L., Tudhope, Susan J., Al-Oanzi, Ziad, Claydon, Amy J., Beynon, Robert J., Towle, Howard C., Agius, Loranne
Format: Artigo
Jezik:Inglês
Izdano: American Diabetes Association 2011
Teme:
Metabolism
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3219956/
https://ncbi.nlm.nih.gov/pubmed/22013014
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db11-0061
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