Glucagon induces translocation of glucokinase from the cytoplasm to the nucleus of hepatocytes by transfer between 6-phosphofructo 2-kinase/fructose 2,6-bisphosphatase-2 and the glucokinase regulatory protein

Glucokinase activity is a major determinant of hepatic glucose metabolism and blood glucose homeostasis. Liver glucokinase activity is regulated acutely by adaptive translocation between the nucleus and the cytoplasm through binding and dissociation from its regulatory protein (GKRP) in the nucleus....

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Main Authors: Cullen, Kirsty S., Al-Oanzi, Ziad H., O'Harte, Finbarr P.M., Agius, Loranne, Arden, Catherine
Formato: Artigo
Idioma:Inglês
Publicado: Elsevier Pub. Co 2014
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4024195/
https://ncbi.nlm.nih.gov/pubmed/24566088
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbamcr.2014.02.006
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