Single Insulin-Specific CD8(+) T Cells Show Characteristic Gene Expression Profiles in Human Type 1 Diabetes

OBJECTIVE: Both the early steps and the high recurrence of autoimmunity once the disease is established are unexplained in human type 1 diabetes. Because CD8(+) T cells are central and insulin is a key autoantigen in the disease process, our objective was to characterize HLA class I–restricted autor...

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Bibliographic Details
Main Authors: Luce, Sandrine, Lemonnier, François, Briand, Jean-Paul, Coste, Joel, Lahlou, Najiba, Muller, Sylviane, Larger, Etienne, Rocha, Benedita, Mallone, Roberto, Boitard, Christian
Format: Artigo
Language:Inglês
Published: American Diabetes Association 2011
Subjects:
Genetics
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3219929/
https://ncbi.nlm.nih.gov/pubmed/21998398
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db11-0270
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