Intercalated Erlotinib-Docetaxel Dosing Schedules Designed to Achieve Pharmacodynamic Separation: Results of a Phase I/II Trial

INTRODUCTION: Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR TKIs) given concurrently with chemotherapy do not improve patient outcomes compared with chemotherapy alone in advanced non-small cell lung cancer (NSCLC). Based on preclinical models, we hypothesized pharmacodynamic sep...

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Main Authors: Sangha, Randeep, Davies, Angela M., Lara, Primo N., Mack, Philip C., Beckett, Laurel A., Hesketh, Paul J., Lau, Derick, Li, Tianhong, Perkins, Natasha, Gandara, David R.
Format: Artigo
Sprog:Inglês
Udgivet: 2011
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3219834/
https://ncbi.nlm.nih.gov/pubmed/21892109
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/JTO.0b013e31822ae061
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