Essential Role of the Small GTPase Ran in Postnatal Pancreatic Islet Development

The small GTPase Ran orchestrates pleiotropic cellular responses of nucleo-cytoplasmic shuttling, mitosis and subcellular trafficking, but whether deregulation of these pathways contributes to disease pathogenesis has remained elusive. Here, we generated transgenic mice expressing wild type (WT) Ran...

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Main Authors: Xia, Fang, Dohi, Takehiko, Martin, Nina M., Raskett, Christopher M., Liu, Qin, Altieri, Dario C.
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2011
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3219697/
https://ncbi.nlm.nih.gov/pubmed/22114719
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0027879
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