Viral Single-Strand DNA Induces p53-Dependent Apoptosis in Human Embryonic Stem Cells

Human embryonic stem cells (hESCs) are primed for rapid apoptosis following mild forms of genotoxic stress. A natural form of such cellular stress occurs in response to recombinant adeno-associated virus (rAAV) single-strand DNA genomes, which exploit the host DNA damage response for replication and...

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Main Authors: Hirsch, Matthew L., Fagan, B. Matthew, Dumitru, Raluca, Bower, Jacquelyn J., Yadav, Swati, Porteus, Matthew H., Pevny, Larysa H., Samulski, R. Jude
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2011
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3219675/
https://ncbi.nlm.nih.gov/pubmed/22114676
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0027520
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