Synergizing metabolic flux analysis and nucleotide sugar metabolism to understand the control of glycosylation of recombinant protein in CHO cells

BACKGROUND: The glycosylation of recombinant proteins can be altered by a range of parameters including cellular metabolism, metabolic flux and the efficiency of the glycosylation process. We present an experimental set-up that allows determination of these key processes associated with the control...

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Main Authors: Burleigh, Susan C, van de Laar, Teun, Stroop, Corné JM, van Grunsven, Wout MJ, O'Donoghue, Niaobh, Rudd, Pauline M, Davey, Gavin P
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2011
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3219575/
https://ncbi.nlm.nih.gov/pubmed/22008152
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1472-6750-11-95
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