Elucidation of the mechanism of selective inhibition of mammalian DNA polymerase alpha by 2-butylanilinopurines: development and characterization of 2-(p-n-butylanilino)adenine and its deoxyribonucleotides.

2-(p-n-Butylanilino)adenine (BuAA), an homolog of the DNA polymerase alpha (pol alpha)-specific inhibitor, N2-(p-n-butylphenyl)guanine (BuPG), was transformed to its 2'-deoxyribonucleoside, BuAdA, and the corresponding 2'-deoxyribonucleoside 5'-phosphates, BuAdAMP, BuAdADP, and BuAdAT...

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Autores principales: Khan, N N, Wright, G E, Dudycz, L W, Brown, N C
Formato: Artigo
Lenguaje:Inglês
Publicado: 1985
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC321956/
https://ncbi.nlm.nih.gov/pubmed/3931053
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