Design and characterization of N2-arylaminopurines which selectively inhibit replicative DNA synthesis and replication-specific DNA polymerases: guanine derivatives active on mammalian DNA polymerase alpha and bacterial DNA polymerase III.

The 2-amino substituted derivatives of guanine, N2-(p-n-butylphenyl)guanine (BuPG) and N2-(3',4'-trimethylenephenyl) guanine (TMPG), were synthesized and found to selectively inhibit, respectively, HeLa cell DNA polymerase alpha (po1 alpha) and B. subtilis DNA polymerase III (po1 III). Bot...

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Detalles Bibliográficos
Publicado en:Nucleic Acids Res
Main Authors: Wright, G E, Baril, E F, Brown, V M, Brown, N C
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 1982
Acceso en liña:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC320811/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6812026/
https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/10.14.4431
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