Design and characterization of N2-arylaminopurines which selectively inhibit replicative DNA synthesis and replication-specific DNA polymerases: guanine derivatives active on mammalian DNA polymerase alpha and bacterial DNA polymerase III.

The 2-amino substituted derivatives of guanine, N2-(p-n-butylphenyl)guanine (BuPG) and N2-(3',4'-trimethylenephenyl) guanine (TMPG), were synthesized and found to selectively inhibit, respectively, HeLa cell DNA polymerase alpha (po1 alpha) and B. subtilis DNA polymerase III (po1 III). Bot...

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Hlavní autoři: Wright, G E, Baril, E F, Brown, V M, Brown, N C
Médium: Artigo
Jazyk:Inglês
Vydáno: 1982
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC320811/
https://ncbi.nlm.nih.gov/pubmed/6812026
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