Defective response of CD4(+ )T cells to retinoic acid and TGFβ in systemic lupus erythematosus

INTRODUCTION: CD25(+ )FOXP3(+ )CD4(+ )regulatory T cells (Tregs) are induced by transforming growth factor β (TGFβ) and further expanded by retinoic acid (RA). We have previously shown that this process was defective in T cells from lupus-prone mice expressing the novel isoform of the Pbx1 gene, Pbx...

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Autors principals: Sobel, Eric S, Brusko, Todd M, Butfiloski, Ed J, Hou, Wei, Li, Shiwu, Cuda, Carla M, Abid, Ariana N, Reeves, Westley H, Morel, Laurence
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2011
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Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3218921/
https://ncbi.nlm.nih.gov/pubmed/21708033
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/ar3387
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