Evaluation of bioactive sphingolipids in 4-HPR-resistant leukemia cells

BACKGROUND: N-(4-hydroxyphenyl)retinamide (4-HPR, fenretinide) is a synthetic retinoid with potent pro-apoptotic activity against several types of cancer, but little is known regarding mechanisms leading to chemoresistance. Ceramide and, more recently, other sphingolipid species (e.g., dihydrocerami...

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Main Authors: Apraiz, Aintzane, Idkowiak-Baldys, Jolanta K, Boyano, María Dolores, Pérez-Yarza, Gorka, Hannun, Yusuf A, Asumendi, Aintzane
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2011
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3218121/
https://ncbi.nlm.nih.gov/pubmed/22061047
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-11-477
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