Arthrogenicity of type II collagen monoclonal antibodies associated with complement activation and antigen affinity

BACKGROUND: The collagen antibody-induced arthritis (CAIA) model, which employs a cocktail of monoclonal antibodies (mAbs) to type II collagen (CII), has been widely used for studying the pathogenesis of autoimmune arthritis. In this model, not all mAbs to CII are capable of inducing arthritis becau...

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Autors principals: Koobkokkruad, Thongchai, Kadotani, Tatsuya, Hutamekalin, Pilaiwanwadee, Mizutani, Nobuaki, Yoshino, Shin
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2011
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3217917/
https://ncbi.nlm.nih.gov/pubmed/22054174
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-9255-8-31
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