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Increased primary tumor growth in mice null for β3- or β3/β5-integrins or selectins

Expression of αvβ3- or αvβ5-integrins and selectins is widespread on blood cells and endothelial cells. Here we report that human tumor cells injected s.c. into mice lacking β3- or β3/β5-integrins or various selectins show enhanced tumor growth compared with growth in control mice. There was increas...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Taverna, Daniela, Moher, Heather, Crowley, Denise, Borsig, Lubor, Varki, Ajit, Hynes, Richard O.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2004
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC321755/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14718670/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0307289101
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