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Dynamic interactions and cooperative functions of PGC-1α and MED1 in TRα-mediated activation of the brown fat-specific UCP-1 gene
PGC-1α is an inducible nuclear receptor coactivator with direct functions in both p300-mediated chromatin remodeling and Mediator-dependent transcription in vitro. Here we have employed the PPARγ- and TRα-activated brown adipose tissue-specific UCP-1 enhancer to investigate mechanistic aspects of PG...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3217464/ https://ncbi.nlm.nih.gov/pubmed/19782026 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2009.09.015 |
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