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Tyrosine phosphorylation within the SH3 domain regulates CAS subcellular localization, cell migration, and invasiveness

Crk-associated substrate (CAS) is a major tyrosine-phosphorylated protein in cells transformed by v-crk and v-src oncogenes and plays an important role in invasiveness of Src-transformed cells. A novel phosphorylation site on CAS, Tyr-12 (Y12) within the ligand-binding hydrophobic pocket of the CAS...

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Bibliografische gegevens
Hoofdauteurs: Janoštiak, Radoslav, Tolde, Ondřej, Brůhová, Zuzana, Novotný , Marian, Hanks, Steven K., Rösel, Daniel, Brábek, Jan
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: The American Society for Cell Biology 2011
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3216652/
https://ncbi.nlm.nih.gov/pubmed/21937722
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E11-03-0207
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