PI3K/AKT is involved in mediating survival signals that rescue Ewing tumour cells from fibroblast growth factor 2-induced cell death

While in vitro studies had shown that fibroblast growth factor 2 (FGF2) can induce cell death in Ewing tumours, it remained unclear how Ewing tumour cells survive in vivo within a FGF2-rich microenvironment. Serum- and integrin-mediated survival signals were, therefore, studied in adherent monolayer...

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Detalhes bibliográficos
Main Authors: Hotfilder, M, Sondermann, P, Senß, A, van Valen, F, Jürgens, H, Vormoor, J
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2005
Assuntos:
Translational Therapeutics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3216036/
https://ncbi.nlm.nih.gov/pubmed/15685229
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6602384
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