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Domain architecture conservation in orthologs

BACKGROUND: As orthologous proteins are expected to retain function more often than other homologs, they are often used for functional annotation transfer between species. However, ortholog identification methods do not take into account changes in domain architecture, which are likely to modify a p...

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Autori principali: Forslund, Kristoffer, Pekkari, Isabella, Sonnhammer, Erik LL
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2011
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3215765/
https://ncbi.nlm.nih.gov/pubmed/21819573
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2105-12-326
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