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Domain architecture conservation in orthologs

BACKGROUND: As orthologous proteins are expected to retain function more often than other homologs, they are often used for functional annotation transfer between species. However, ortholog identification methods do not take into account changes in domain architecture, which are likely to modify a p...

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Detalhes bibliográficos
Main Authors: Forslund, Kristoffer, Pekkari, Isabella, Sonnhammer, Erik LL
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3215765/
https://ncbi.nlm.nih.gov/pubmed/21819573
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2105-12-326
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