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Domain architecture conservation in orthologs

BACKGROUND: As orthologous proteins are expected to retain function more often than other homologs, they are often used for functional annotation transfer between species. However, ortholog identification methods do not take into account changes in domain architecture, which are likely to modify a p...

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書目詳細資料
Main Authors: Forslund, Kristoffer, Pekkari, Isabella, Sonnhammer, Erik LL
格式: Artigo
語言:Inglês
出版: BioMed Central 2011
主題:
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3215765/
https://ncbi.nlm.nih.gov/pubmed/21819573
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2105-12-326
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