Fibroblastic Reticular Cells From Lymph Nodes Attenuate T Cell Expansion by Producing Nitric Oxide

Adaptive immune responses are initiated when T cells encounter antigen on dendritic cells (DC) in T zones of secondary lymphoid organs. T zones contain a 3-dimensional scaffold of fibroblastic reticular cells (FRC) but currently it is unclear how FRC influence T cell activation. Here we report that...

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Main Authors: Siegert, Stefanie, Huang, Hsin-Ying, Yang, Chen-Ying, Scarpellino, Leonardo, Carrie, Lucie, Essex, Sarah, Nelson, Peter J., Heikenwalder, Matthias, Acha-Orbea, Hans, Buckley, Christopher D., Marsland, Benjamin J., Zehn, Dietmar, Luther, Sanjiv A.
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2011
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3215737/
https://ncbi.nlm.nih.gov/pubmed/22110693
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0027618
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