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ER and PI3K independently modulate endocrine resistance in ER positive breast cancer

Endocrine Therapy Resistant Estrogen Receptor Positive (ER+) Breast Cancer is the most common cause of breast cancer death. Miller et al. demonstrate that ligand-independent ER activity promotes the growth of breast cancer cells through CDK4/E2F. As an independent event the PI3K pathway is also up r...

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Autori principali: Van Tine, Brian A., Crowder, Robert J., Ellis, Matthew J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2011
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3215586/
https://ncbi.nlm.nih.gov/pubmed/22096658
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-11-0192
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