Characterizing genetic interactions in human disease association studies using statistical epistasis networks

BACKGROUND: Epistasis is recognized ubiquitous in the genetic architecture of complex traits such as disease susceptibility. Experimental studies in model organisms have revealed extensive evidence of biological interactions among genes. Meanwhile, statistical and computational studies in human popu...

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Main Authors: Hu, Ting, Sinnott-Armstrong, Nicholas A, Kiralis, Jeff W, Andrew, Angeline S, Karagas, Margaret R, Moore, Jason H
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2011
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3215301/
https://ncbi.nlm.nih.gov/pubmed/21910885
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2105-12-364
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