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Polyhead formation in phage P22 pinpoints a region in coat protein required for conformational switching

Eighteen single amino acid substitutions in phage P22 coat protein cause temperature-sensitive folding defects (tsf). Three intragenic global suppressor (su) substitutions (D163G, T166I and F170L), localized to a flexible loop, rescue the folding of several tsf coat proteins. Here we investigate the...

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Bibliografski detalji
Glavni autori: Parent, Kristin N., Suhanovsky, Margaret M., Teschke, Carolyn M.
Format: Artigo
Jezik:Inglês
Izdano: 2007
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3215258/
https://ncbi.nlm.nih.gov/pubmed/17680786
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2958.2007.05868.x
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