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Determinants of bacteriophage P22 polyhead formation: the role of coat protein flexibility in conformational switching

We have investigated determinants of polyhead formation in bacteriophage P22 in order to understand the molecular mechanism by which coat protein assembly goes astray. Polyhead assembly is caused by amino acid substitutions in coat protein at position 170, which is located in the β– hinge. In vivo s...

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Détails bibliographiques
Auteurs principaux: Suhanovsky, Margaret M., Parent, Kristin N., Dunn, Sarah E., Baker, Timothy S., Teschke, Carolyn M.
Format: Artigo
Langue:Inglês
Publié: 2010
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2945288/
https://ncbi.nlm.nih.gov/pubmed/20659287
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2958.2010.07311.x
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