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Determinants of bacteriophage P22 polyhead formation: the role of coat protein flexibility in conformational switching

We have investigated determinants of polyhead formation in bacteriophage P22 in order to understand the molecular mechanism by which coat protein assembly goes astray. Polyhead assembly is caused by amino acid substitutions in coat protein at position 170, which is located in the β– hinge. In vivo s...

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Detalhes bibliográficos
Main Authors: Suhanovsky, Margaret M., Parent, Kristin N., Dunn, Sarah E., Baker, Timothy S., Teschke, Carolyn M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2945288/
https://ncbi.nlm.nih.gov/pubmed/20659287
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2958.2010.07311.x
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