Coupling of FcγRI to FcγRIIB by Src Kinase Mediates C-reactive Protein Impairment of Endothelial Function

RATIONALE: Elevations in C-reactive protein (CRP) are associated with increased cardiovascular disease risk and endothelial dysfunction. CRP antagonizes endothelial NO synthase (eNOS) through processes mediated by the IgG receptor Fcγ receptor IIB (FcγRIIB), its immunoreceptor tyrosine-based inhibit...

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Autores principales: Sundgren, Nathan C., Zhu, Weifei, Yuhanna, Ivan S., Chambliss, Ken L., Ahmed, Mohamed, Tanigaki, Keiji, Umetani, Michihisa, Mineo, Chieko, Shaul, Philip W.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2011
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3215097/
https://ncbi.nlm.nih.gov/pubmed/21940940
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.111.254573
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