Hyposialylated IgG activates endothelial IgG receptor FcγRIIB to promote obesity-induced insulin resistance

Type 2 diabetes mellitus (T2DM) is a common complication of obesity. Here, we have shown that activation of the IgG receptor FcγRIIB in endothelium by hyposialylated IgG plays an important role in obesity-induced insulin resistance. Despite becoming obese on a high-fat diet (HFD), mice lacking FcγRI...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Tanigaki, Keiji, Sacharidou, Anastasia, Peng, Jun, Chambliss, Ken L., Yuhanna, Ivan S., Ghosh, Debabrata, Ahmed, Mohamed, Szalai, Alexander J., Vongpatanasin, Wanpen, Mattrey, Robert F., Chen, Qiushi, Azadi, Parastoo, Lingvay, Ildiko, Botto, Marina, Holland, William L., Kohler, Jennifer J., Sirsi, Shashank R., Hoyt, Kenneth, Shaul, Philip W., Mineo, Chieko
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5749535/
https://ncbi.nlm.nih.gov/pubmed/29202472
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI89333
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