Pharmacokinetics of DA-7867, a New Oxazolidinone, after Intravenous or Oral Administration to Rats: Intestinal First-Pass Effect

Pharmacokinetic parameters of DA-7867 were dose independent after both intravenous administration and oral administration (at doses of 1 to 20 mg/kg of body weight) to rats. After oral administration of DA-7867 to rats at a dose of 10 mg/kg, approximately 8.27% of oral dose was not absorbed from the...

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Veröffentlicht in:	Antimicrob Agents Chemother
Hauptverfasser:	Bae, Soo K., Chung, Won-Suk, Kim, Eun J., Rhee, Jae K., Kwon, Jong W., Kim, Won B., Lee, Myung G.
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Microbiology (ASM) 2004
Schlagworte:	Pharmacology
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC321507/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14742232/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.48.2.659-662.2004
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