Pharmacokinetics of DA-7867, a New Oxazolidinone, after Intravenous or Oral Administration to Rats: Intestinal First-Pass Effect

Pharmacokinetic parameters of DA-7867 were dose independent after both intravenous administration and oral administration (at doses of 1 to 20 mg/kg of body weight) to rats. After oral administration of DA-7867 to rats at a dose of 10 mg/kg, approximately 8.27% of oral dose was not absorbed from the...

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Detalhes bibliográficos
Main Authors: Bae, Soo K., Chung, Won-Suk, Kim, Eun J., Rhee, Jae K., Kwon, Jong W., Kim, Won B., Lee, Myung G.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2004
Assuntos:
Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC321507/
https://ncbi.nlm.nih.gov/pubmed/14742232
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.48.2.659-662.2004
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