Effects of Cilastatin on the Pharmacokinetics of a New Carbapenem, DA-1131, in Rats, Rabbits, and Dogs

DA-1131, a new carbapenem antibiotic, undergoes renal metabolism by renal dehydropeptidase I (DHP-I), located on the brush border of the proximal tubular cell. Species differences with regard to the effects of cilastatin, a renal DHP-I inhibitor, were investigated after a 1-min intravenous infusion...

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Detalles Bibliográficos

Publicado en:	Antimicrob Agents Chemother
Autores principales:	Kim, So H., Kwon, Jong W., Kim, Won B., Lee, Myung G.
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	American Society for Microbiology (ASM) 1999
Materias:	Pharmacology
Acceso en línea:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC89513/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10508037/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.43.10.2524
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