Cd8 enhancer E8(I) and Runx factors regulate CD8α expression in activated CD8(+) T cells

Cd8a and Cd8b1 coreceptor gene (Cd8) expression is tightly controlled during T-cell development by the activity of five Cd8 enhancers (E8(I)–E8(V)). Here we demonstrate a unique transcriptional program regulating CD8 expression during CD8(+) effector T-cell differentiation. The Cd8 enhancer E8(I) an...

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Main Authors: Hassan, Hammad, Sakaguchi, Shinya, Tenno, Mari, Kopf, Aglaja, Boucheron, Nicole, Carpenter, Andrea C., Egawa, Takeshi, Taniuchi, Ichiro, Ellmeier, Wilfried
Formáid: Artigo
Teanga:Inglês
Foilsithe: National Academy of Sciences 2011
Ábhair:
Biological Sciences
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3215065/
https://ncbi.nlm.nih.gov/pubmed/22025728
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1105835108
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