Cell culture model that mimics drusen formation and triggers complement activation associated with age-related macular degeneration

We introduce a human retinal pigmented epithelial (RPE) cell-culture model that mimics several key aspects of early stage age-related macular degeneration (AMD). These include accumulation of sub-RPE deposits that contain molecular constituents of human drusen, and activation of complement leading t...

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Autors principals: Johnson, Lincoln V., Forest, David L., Banna, Christopher D., Radeke, Carolyn M., Maloney, Michelle A., Hu, Jane, Spencer, Christine N., Walker, Aimee M., Tsie, Marlene S., Bok, Dean, Radeke, Monte J., Anderson, Don H.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2011
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3215058/
https://ncbi.nlm.nih.gov/pubmed/21969589
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1109703108
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