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The Alzheimer's Aβ-peptide is deposited at sites of complement activation in pathologic deposits associated with aging and age-related macular degeneration

Age-related macular degeneration (AMD) is a leading cause of irreversible vision loss in older individuals worldwide. The disease is characterized by abnormal extracellular deposits, known as drusen, that accumulate along the basal surface of the retinal pigmented epithelium. Although drusen deposit...

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Detalhes bibliográficos
Main Authors: Johnson, Lincoln V., Leitner, William P., Rivest, Alexander J., Staples, Michelle K., Radeke, Monte J., Anderson, Don H.
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences 2002
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC129354/
https://ncbi.nlm.nih.gov/pubmed/12189211
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.192203399
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