ΔNp63α regulates keratinocyte proliferation by controlling PTEN expression and localization

ΔNp63α, implicated as an oncogene, is upregulated by activated Akt, part of a well-known cell survival pathway. Inhibition of Akt activation by phosphatase and tensin homolog deleted on chromosome 10 (PTEN) and the presence of putative p63-binding sites in the pten promoter led us to investigate whe...

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Bibliografske podrobnosti
Main Authors: Leonard, M K, Kommagani, R, Payal, V, Mayo, L D, Shamma, H N, Kadakia, M P
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2011
Teme:
Original Paper
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3214913/
https://ncbi.nlm.nih.gov/pubmed/21637289
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2011.73
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