E3 ubiquitin ligase Hades negatively regulates the exonuclear function of p53

Following DNA damage, p53 translocates to the cytoplasm and mitochondria, where it triggers transcription-independent apoptosis by binding to Bcl-2 family proteins. However, little is known about how this exonuclear function of p53 is regulated. Here, we identify and characterize a p53-interacting p...

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Detalhes bibliográficos
Main Authors: Jung, J H, Bae, S, Lee, J Y, Woo, S R, Cha, H J, Yoon, Y, Suh, K-S, Lee, S-J, Park, I-C, Jin, Y-W, Lee, K-H, An, S, Lee, J H
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2011
Assuntos:
Original Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3214910/
https://ncbi.nlm.nih.gov/pubmed/21597459
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2011.57
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