MAOS ls for the general synthesis and lead optimization of 3,6-disubstituted-[1,2,4]triazolo[4,3-b]pyridazines

General, high-yielding MAOS protocols for the expedient synthesis of functionalized 3,6-disubstituted-[1,2,4]triazolo[4,3-b]pyridazines are described amenable to an iterative analog library synthesis strategy for the lead optimization of an M1 antagonist screening hit. Optimized compounds proved to...

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Detalhes bibliográficos
Main Authors: Aldrich, Leslie N., Lebois, Evan P., Lewis, L. Michelle, Nalywajko, Natalia T., Niswender, Colleen M., Weaver, C. David, Conn, P. Jeffrey, Lindsley, Craig W.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3214729/
https://ncbi.nlm.nih.gov/pubmed/22090663
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tetlet.2008.10.127
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