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Flavopiridol induces BCL-2 expression and represses oncogenic transcription factors in leukemic blasts from adults with refractory acute myeloid leukemia

Flavopiridol is a cyclin-dependent kinase inhibitor that induces cell cycle arrest, apoptosis, and clinical responses in selected patients with acute myeloid leukemia (AML). A better understanding of the molecular pathways targeted by flavopiridol is needed to design optimal combinatorial therapy. H...

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Detalhes bibliográficos
Main Authors: Nelson, Dwella M., Joseph, Biju, Hillion, Joelle, Segal, Jodi, Karp, Judith E., Resar, Linda M. S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3214625/
https://ncbi.nlm.nih.gov/pubmed/21728742
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3109/10428194.2011.591012
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