An Extensive MicroRNA-Mediated Network of RNA-RNA Interactions Regulates Established Oncogenic Pathways in Glioblastoma

By analyzing gene expression data in gliobastoma in combination with matched microRNA profiles, we have uncovered a post-transcriptional regulation layer of surprising magnitude, comprising over 248,000 microRNA (miR)-mediated interactions. These include ~7,000 genes whose transcripts act as miR ‘sp...

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Main Authors: Sumazin, Pavel, Yang, Xuerui, Chiu, Hua-Sheng, Chung, Wei-Jen, Iyer, Archana, Llobet-Navas, David, Rajbhandari, Presha, Bansal, Mukesh, Guarnieri, Paolo, Silva, Jose, Califano, Andrea
Format: Artigo
Jezik:Inglês
Izdano: 2011
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3214599/
https://ncbi.nlm.nih.gov/pubmed/22000015
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2011.09.041
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