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Simultaneous single-molecule mapping of protein-DNA interactions and DNA methylation by MAPit
Sites of protein binding to DNA are inferred from footprints or spans of protection against a probing reagent. In most protocols, sites of accessibility to a probe are detected by mapping breaks in DNA strands. As discussed in this unit, such methods obscure molecular heterogeneity by averaging cuts...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
2011
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3214598/ https://ncbi.nlm.nih.gov/pubmed/21732317 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/0471142727.mb2122s95 |
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