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Continuous Zebularine Treatment Effectively Sustains Demethylation in Human Bladder Cancer Cells

During tumorigenesis, tumor suppressor and cancer-related genes are commonly silenced by aberrant DNA methylation in their promoter regions. Recently, we reported that zebularine [1-(β-d-ribofuranosyl)-1,2-dihydropyrimidin-2-one] acts as an inhibitor of DNA methylation and exhibits chemical stabilit...

תיאור מלא

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מידע ביבליוגרפי
Main Authors: Cheng, Jonathan C., Weisenberger, Daniel J., Gonzales, Felicidad A., Liang, Gangning, Xu, Guo-Liang, Hu, Ye-Guang, Marquez, Victor E., Jones, Peter A.
פורמט: Artigo
שפה:Inglês
יצא לאור: American Society for Microbiology 2004
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC321446/
https://ncbi.nlm.nih.gov/pubmed/14729971
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.24.3.1270-1278.2004
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