Nicotinamide Clearance by Pnc1 Directly Regulates Sir2-Mediated Silencing and Longevity

The Saccharomyces cerevisiae Sir2 protein is an NAD(+)-dependent histone deacetylase (HDAC) that functions in transcriptional silencing and longevity. The NAD(+) salvage pathway protein, Npt1, regulates Sir2-mediated processes by maintaining a sufficiently high intracellular NAD(+) concentration. Ho...

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Detalhes bibliográficos

Publicado no:	Mol Cell Biol
Principais autores:	Gallo, Christopher M., Smith, Daniel L., Smith, Jeffrey S.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Taylor & Francis 2004
Assuntos:	Transcriptional Regulation
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC321434/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14729974/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.24.3.1301-1312.2004
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