ASPP1 and ASPP2: Common Activators of p53 Family Members

We recently showed that ASPP1 and ASPP2 stimulate the apoptotic function of p53. We show here that ASPP1 and ASPP2 also induce apoptosis independently of p53. By binding to p63 and p73 in vitro and in vivo, ASPP1 and ASPP2 stimulate the transactivation function of p63 and p73 on the promoters of Bax...

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Autores principales: Bergamaschi, Daniele, Samuels, Yardena, Jin, Boquan, Duraisingham, Sai, Crook, Tim, Lu, Xin
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2004
Materias:
Cell Growth and Development
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC321425/
https://ncbi.nlm.nih.gov/pubmed/14729977
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.24.3.1341-1350.2004
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