The Immediate-Early 63 Protein of Varicella-Zoster Virus: Analysis of Functional Domains Required for Replication In Vitro and for T-Cell and Skin Tropism in the SCIDhu Model In Vivo

The immediate-early 63-kDa (IE63) protein of varicella-zoster virus (VZV) is a phosphoprotein encoded by open reading frame (ORF) ORF63/ORF70. To identify functional domains, 22 ORF63 mutations were evaluated for effects on IE63 binding to the major VZV transactivator, IE62, and on IE63 phosphorylat...

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Publicat a:	J Virol
Autors principals:	Baiker, Armin, Bagowski, Christoph, Ito, Hideki, Sommer, Marvin, Zerboni, Leigh, Fabel, Klaus, Hay, John, Ruyechan, William, Arvin, Ann M.
Format:	Artigo
Idioma:	Inglês
Publicat:	American Society for Microbiology (ASM) 2004
Matèries:	Replication
Accés en línia:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC321405/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14722273/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JVI.78.3.1181-1194.2004
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