The Immediate-Early 63 Protein of Varicella-Zoster Virus: Analysis of Functional Domains Required for Replication In Vitro and for T-Cell and Skin Tropism in the SCIDhu Model In Vivo

The immediate-early 63-kDa (IE63) protein of varicella-zoster virus (VZV) is a phosphoprotein encoded by open reading frame (ORF) ORF63/ORF70. To identify functional domains, 22 ORF63 mutations were evaluated for effects on IE63 binding to the major VZV transactivator, IE62, and on IE63 phosphorylat...

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Autores principales: Baiker, Armin, Bagowski, Christoph, Ito, Hideki, Sommer, Marvin, Zerboni, Leigh, Fabel, Klaus, Hay, John, Ruyechan, William, Arvin, Ann M.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2004
Materias:
Replication
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC321405/
https://ncbi.nlm.nih.gov/pubmed/14722273
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.78.3.1181-1194.2004
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