Construction of Varicella-Zoster Virus Recombinants from Parent Oka Cosmids and Demonstration that ORF65 Protein Is Dispensable for Infection of Human Skin and T Cells in the SCID-hu Mouse Model

We generated an ORF65 deletion mutant by using a cosmid system constructed from the genome of a low-passage clinical isolate (P-Oka). Using the SCID-hu mouse model, we demonstrated that the ORF65 protein is dispensable for viral replication in skin and T cells, which are critical host cell targets d...

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Bibliographic Details
Main Authors: Niizuma, Takahiro, Zerboni, Leigh, Sommer, Marvin H., Ito, Hideki, Hinchliffe, Stewart, Arvin, Ann M.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2003
Subjects:
Virus-Cell Interactions
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC154042/
https://ncbi.nlm.nih.gov/pubmed/12719598
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.77.10.6062-6065.2003
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