Construction of Varicella-Zoster Virus Recombinants from Parent Oka Cosmids and Demonstration that ORF65 Protein Is Dispensable for Infection of Human Skin and T Cells in the SCID-hu Mouse Model

We generated an ORF65 deletion mutant by using a cosmid system constructed from the genome of a low-passage clinical isolate (P-Oka). Using the SCID-hu mouse model, we demonstrated that the ORF65 protein is dispensable for viral replication in skin and T cells, which are critical host cell targets d...

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Detalhes bibliográficos

Publicado no:	J Virol
Principais autores:	Niizuma, Takahiro, Zerboni, Leigh, Sommer, Marvin H., Ito, Hideki, Hinchliffe, Stewart, Arvin, Ann M.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 2003
Assuntos:	Virus-Cell Interactions
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC154042/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12719598/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JVI.77.10.6062-6065.2003
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