Decreased tetrahydrobiopterin and disrupted association of Hsp90 with eNOS by hyperglycemia impair myocardial ischemic preconditioning

Cardioprotection by ischemic preconditioning (IPC) is impaired during hyperglycemia, but the mechanisms underlying this phenomenon are poorly understood. This study investigated the role of hyperglycemia to adversely modulate tetrahydrobiopterin (BH(4)) and heat shock protein 90 (Hsp90) during cardi...

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Detalhes bibliográficos
Main Authors: Vladic, Nikolina, Ge, Zhi-Dong, Leucker, Thorsten, Brzezinska, Anna K., Du, Jian-Hai, Shi, Yang, Warltier, David C., Pratt, Phillip F., Kersten, Judy R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2011
Assuntos:
Integrative Cardiovascular Physiology and Pathophysiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3213977/
https://ncbi.nlm.nih.gov/pubmed/21908789
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.01078.2010
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