Hyperglycemia Adversely Modulates Endothelial Nitric Oxide Synthase during Anesthetic Preconditioning through Tetrahydrobiopterin- and Heat Shock Protein 90- Mediated Mechanisms

BACKGROUND: Endothelial nitric oxide synthase activity is regulated by tetrahydrobiopterin (BH(4)) and heat shock protein 90. We tested the hypothesis that hyperglycemia abolishes anesthetic preconditioning (APC) through BH(4)- and heat shock protein 90-dependent pathways. METHODS: Myocardial infarc...

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Detalhes bibliográficos
Main Authors: Amour, Julien, Brzezinska, Anna K., Jager, Zachary, Sullivan, Corbin, Weihrauch, Dorothee, Du, Jianhai, Vladic, Nikolina, Shi, Yang, Warltier, David C., Pratt, Phillip F., Kersten, Judy R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2888104/
https://ncbi.nlm.nih.gov/pubmed/20124983
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/ALN.0b013e3181cded1f
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